Skepfeeds-The Best Skeptical blogs of the day

No Benefit from Gingko

Posted in Neurologica by Skepdude on November 26, 2008

Gingko biloba is widely used as a supplement (even though it is really an herbal drug) to improve memory to help treat or prevent dementia. However, there are no quality trials showing that it is effective. This month in JAMA is published the results of a study that has been going on for the past 8 years looking at ginkgo in elderly patients. I have actually been waiting for these results for a while – a large and fairly definitive trial to end the debates about the significance of the preliminary data we have had so far.

The results did not surprise me – after following 3069 subjects for an average of 6.1 years, the study concluded:

In this study, G biloba at 120 mg twice a day was not effective in reducing either the overall incidence rate of dementia or AD incidence in elderly individuals with normal cognition or those with MCI. (MCI = minimal cognitive impairment)

Therefore the best data we have to date – the results of a very large, well controlled, and highly anticipated trial – gingko does not work. It is always interesting, once such trials have come to light, to then look back at the previous research to see how it compares. What we find is a pattern of suggestively positive studies. Basic science data, for example, showed that gingko extract may reduce amyloid precursor protein in mice – this is a protein that builds up in Alzheimer’s disease. Preliminary clinical trials were mixed but tended to be positive.

READ THE REST OF THIS ENTRY AT “NEUROLOGICA”

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